In conjunction with African colleagues, the team at Harvard School of Public Health has begun an ambitious project to start cohort studies that include 500,000 participants across Nigeria, Uganda, Tanzania, and South Africa. They will make innovative use of technology to keep costs down. For example, with cell phones––widely used across all of Africa––they can retrieve data and conduct follow-up surveys with participants. They plan to develop comprehensive biobank to enable cutting edge molecular studies. The large number of participants will allow the study of gene and environment interactions. And, as has been effectively demonstrated with studies here in the United States, PaCT will provide a fertile training ground in innovative research and create viable career paths for African scientists. Furthermore, PaCT will allow for collaboration between African countries, as well as partnerships with more developed countries.